ABSTRACT
Objective To explore the effect of individualized contrast agent injection regimen on coronary artery enhancement based on body surface area (BSA) and body weight (BW).Methods Totally 300 patients with suspected coronary heart disease from January to December 2016 in our hospital were randomly divided into three groups:control group (the injection volume and flow rate were fixed),BSA adjustment group and BW adjustment group.The patients were detected by CTA,and the degree and quality of coronary artery enhancement,the amount and flow rate of contrast agent,and the safety were analyzed in the three groups.Results The coronary artery enhancement value of the BSA adjustment group and the BW adjustment group was significantly higher than that of the control group (P＜0.05).The coronary enhancement in the BSA adjustment group was significantly higher than that of the BW adjustment group.Moreover,the standard deviation of the BSA adjustment group was significantly lower than that of the BW adjustment group (P＜0.05).The CTA score of the BSA adjustment group was significantly higher than that of the control group (P＜0.05).However,there was no significant difference between the BW adjustment group and BSA adjustment group or the control group (P＞0.05).The contrast agent dosage and flow rate was significantly higher in the control group than in the BSA adjustment group and BW adjustment group (P＜0.05).However,there was no significant difference between the BW adjustment group and BSA adjustment group (P＞0.05).Also,there was no significant difference in safety index between the three groups (P＞0.05).Conclusion The individualized contrast agent injection program based on BSA adjustment could not only reduce the amount of coronary imaging contrast agent and flow rate,but also improve the degree and effect of coronary artery enhancement.It could be expected to become a technical means for screening,early diagnosis,and even early intervention in early coronary heart disease.